Spinal Ceramide Modulates the Development of Morphine Antinociceptive Tolerance via Peroxynitrite-Mediated Nitroxidative Stress and Neuroimmune Activation

The effective treatment of pain is typically limited by a decrease in the pain-relieving action of morphine that follows its chronic administration (tolerance). Therefore, restoring opioid efficacy is of great clinical importance. In a murine model of opioid antinociceptive tolerance, repeated admin...

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Autori principali: Ndengele, Michael M., Cuzzocrea, Salvatore, Masini, Emanuela, Vinci, M. Cristina, Esposito, Emanuela, Muscoli, Carolina, Petrusca, Daniela Nicoleta, Mollace, Vincenzo, Mazzon, Emanuela, Li, Dechun, Petrache, Irina, Matuschak, George M., Salvemini, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Pharmacology and Experimental Therapeutics 2009
Soggetti:
Neuropharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670603/
https://ncbi.nlm.nih.gov/pubmed/19033555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.146290
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