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Transforming Growth Factor β Depletion Is the Primary Determinant of Smad Signaling Kinetics

A cell's decision to growth arrest, apoptose, or differentiate in response to transforming growth factor β (TGF-β) superfamily ligands depends on the ligand concentration. How cells sense the concentration of extracellular bioavailable TGF-β remains poorly understood. We therefore undertook a s...

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Detalhes bibliográficos
Main Authors: Clarke, David C., Brown, Meredith L., Erickson, Richard A., Shi, Yigong, Liu, Xuedong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668365/
https://ncbi.nlm.nih.gov/pubmed/19223462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01443-08
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