Homocysteine effects classical pathway of GPCR down regulation: Gα(q/11), Gα(12/13), G(i/o)

G protein-coupled receptors (GPCRs) are known to modulate intracellular effectors involved in cardiac function. We recently reported homocysteine (Hcy)-induced ERK-phosphorylation was suppressed by pertussis toxin (PTX), which suggested the involvement of GPCRs in initiating signal transduction. An...

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Bibliographic Details
Main Authors: Vacek, T. P., Sen, U., Tyagi, N., Kumar, M., Moshal, K. S., Passmore, J. C., Tyagi, S. C.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667933/
https://ncbi.nlm.nih.gov/pubmed/18777088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-008-9904-4
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