Hippocampal Gα(q/11) but not Gα(o)-coupled receptors are altered in aging

Normal aging may limit the signaling efficacy of certain GPCRs by disturbing the function of specific Gα-subunits and leading to deficient modulation of intracellular functions that subserve synaptic plasticity, learning and memory. Evidence suggests that Gα(q/11) is more sensitive to the effects of...

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Main Authors: McQuail, Joseph A., Davis, Kathleen N., Miller, Frances, Hampson, Robert E., Deadwyler, Samuel A., Howlett, Allyn C., Nicolle, Michelle M.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705722/
https://ncbi.nlm.nih.gov/pubmed/23347951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.01.009
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