Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

Translesion synthesis (TLS) is a DNA damage tolerance mechanism that allows continued DNA synthesis, even in the presence of damaged DNA templates. Mammals have multiple DNA polymerases specialized for TLS, including Polη, Polι, and Polκ. These enzymes show preferential bypass for different lesions....

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Bibliographische Detailangaben
Hauptverfasser: Hishiki, Asami, Hashimoto, Hiroshi, Hanafusa, Tomo, Kamei, Keijiro, Ohashi, Eiji, Shimizu, Toshiyuki, Ohmori, Haruo, Sato, Mamoru
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667742/
https://ncbi.nlm.nih.gov/pubmed/19208623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809745200
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