Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

Translesion synthesis (TLS) is a DNA damage tolerance mechanism that allows continued DNA synthesis, even in the presence of damaged DNA templates. Mammals have multiple DNA polymerases specialized for TLS, including Polη, Polι, and Polκ. These enzymes show preferential bypass for different lesions....

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Detalhes bibliográficos
Main Authors: Hishiki, Asami, Hashimoto, Hiroshi, Hanafusa, Tomo, Kamei, Keijiro, Ohashi, Eiji, Shimizu, Toshiyuki, Ohmori, Haruo, Sato, Mamoru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667742/
https://ncbi.nlm.nih.gov/pubmed/19208623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809745200
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