Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNγ production

IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN γ...

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Main Authors: Lemos, Henrique P., Grespan, Renata, Vieira, Silvio M., Cunha, Thiago M., Verri, Waldiceu A., Fernandes, Karla S. S., Souto, Fabricio O., McInnes, Iain B., Ferreira, Sergio H., Liew, Foo Y., Cunha, Fernando Q.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667068/
https://ncbi.nlm.nih.gov/pubmed/19289819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812782106
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