IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-γ, endothelin, and prostaglandin

IL-15 is closely associated with inflammatory diseases. IL-15 targeting is effective in treating experimental and clinical rheumatoid arthritis (RA). Because hyperalgesia accompanies RA, we investigated the ability of IL-15 to induced nociceptor sensitization (hypernociception). We report here that...

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Hauptverfasser: Verri, Waldiceu A., Cunha, Thiago M., Parada, Carlos A., Wei, Xiao-qing, Ferreira, Sérgio Henrique, Liew, Foo Y., Cunha, Fernando Q.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480473/
https://ncbi.nlm.nih.gov/pubmed/16766656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603286103
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