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Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

The pathological mechanism by which Aβ causes neuronal dysfunction and death remains largely unknown. Deficiencies in fast axonal transport (FAT) were suggested to play a crucial role in neuronal dysfunction and loss for a diverse set of dying back neuropathologies including Alzheimer's disease...

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Hlavní autoři: Pigino, G., Morfini, G., Atagi, Y., Deshpande, A., Yu, C., Jungbauer, L., LaDu, M., Busciglio, J., Brady, S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667037/
https://ncbi.nlm.nih.gov/pubmed/19321417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901229106
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