1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C

Parkinson's disease (PD), a late-onset condition characterized by dysfunction and loss of dopaminergic neurons in the substantia nigra, has both sporadic and neurotoxic forms. Neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its metabolite 1-methyl-4-phenylpyridinium (MPP+)...

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Detalhes bibliográficos
Main Authors: Morfini, G., Pigino, G., Opalach, K., Serulle, Y., Moreira, J. E., Sugimori, M., Llinás, R. R., Brady, S. T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892945/
https://ncbi.nlm.nih.gov/pubmed/17287338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611231104
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