Pathogenic Huntingtin Inhibits Fast Axonal Transport by Activating JNK3 and Phosphorylating Kinesin

Selected vulnerability of neurons in Huntington’s disease (HD) suggests alterations in a cellular process particularly critical for neuronal function. Supporting this idea, pathogenic Htt (polyQ-Htt) inhibits fast axonal transport (FAT) in various cellular and animal HD models (mouse and squid), but...

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Main Authors: Morfini, Gerardo A, You, Yi-Mei, Pollema, Sarah L, Kaminska, Agnieszka, Liu, Katherine, Yoshioka, Katsuji, Björkblom, Benny, Coffey, Eleanor T., Bagnato, Carolina, Han, David, Huang, Chun-Fang, Banker, Gary, Pigino, Gustavo, Brady, Scott T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739046/
https://ncbi.nlm.nih.gov/pubmed/19525941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2346
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