Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined. Characteristics of motor neurons affected in FA...

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Main Authors: Morfini, Gerardo A., Bosco, Daryl A., Brown, Hannah, Gatto, Rodolfo, Kaminska, Agnieszka, Song, Yuyu, Molla, Linda, Baker, Lisa, Marangoni, M. Natalia, Berth, Sarah, Tavassoli, Ehsan, Bagnato, Carolina, Tiwari, Ashutosh, Hayward, Lawrence J., Pigino, Gustavo F., Watterson, D. Martin, Huang, Chun-Fang, Banker, Gary, Brown, Robert H., Brady, Scott T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680447/
https://ncbi.nlm.nih.gov/pubmed/23776455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065235
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