ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation

Mutations in Fused in Sarcoma/Translocated in Liposarcoma (FUS) cause familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive axonal degeneration mainly affecting motor neurons. Evidence from transgenic mouse models suggests mutant forms of FUS...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sama, Reddy Ranjith K., Fallini, Claudia, Gatto, Rodolfo, McKeon, Jeanne E., Song, Yuyu, Rotunno, Melissa S., Penaranda, Saul, Abdurakhmanov, Izrail, Landers, John E., Morfini, Gerardo, Brady, Scott T., Bosco, Daryl A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428330/
https://ncbi.nlm.nih.gov/pubmed/28273913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00091-1
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