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Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues
Hyaluronidases are a family of endolytic glycoside hydrolases that cleave the β1-4 linkage between N-acetylglucosamine and glucuronic acid in hyaluronan polymers via a substrate-assisted mechanism. In humans, turnover of hyaluronan by this enzyme family is critical for normal extracellular matrix re...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2666596/ https://ncbi.nlm.nih.gov/pubmed/19201751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900210200 |
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