UDP-glucose Dehydrogenase Activity and Optimal Downstream Cellular Function Require Dynamic Reorganization at the Dimer-Dimer Subunit Interfaces

UDP-glucose dehydrogenase (UGDH) provides precursors for steroid elimination, hyaluronan production, and glycosaminoglycan synthesis. The wild-type UGDH enzyme purifies in a hexamer-dimer equilibrium and transiently undergoes dynamic motion that exposes the dimer-dimer interface during catalysis. In...

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Detalhes bibliográficos
Main Authors: Hyde, Annastasia S., Thelen, Ashley M., Barycki, Joseph J., Simpson, Melanie A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853257/
https://ncbi.nlm.nih.gov/pubmed/24145036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.519090
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