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Inhibiting hexamer disassembly of human UDP-glucose dehydrogenase by photoactivated amino acid crosslinking
The enzyme UDP-glucose dehydrogenase (UGDH) catalyzes the reaction of UDP-glucose to UDP-glucuronate through two successive NAD(+)-dependent oxidation steps. Human UGDH apoprotein purifies as a mixture of dimeric and hexameric species. Addition of substrate and cofactor stabilizes the oligomeric sta...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955856/ https://ncbi.nlm.nih.gov/pubmed/27198584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00259 |
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