Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking

Hyaluronan (HA) turnover accelerates metastatic progression of prostate cancer in part by increasing rates of tumor cell proliferation and motility. To determine the mechanism, we overexpressed hyaluronidase 1 (Hyal1) as a fluorescent fusion protein and examined its impact on endocytosis and vesicul...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: McAtee, Caitlin O., Berkebile, Abigail R., Elowsky, Christian G., Fangman, Teresa, Barycki, Joseph J., Wahl, James K., Khalimonchuk, Oleh, Naslavsky, Naava, Caplan, Steve, Simpson, Melanie A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505569/
https://ncbi.nlm.nih.gov/pubmed/25855794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.647446
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