Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues

Hyaluronidases are a family of endolytic glycoside hydrolases that cleave the β1-4 linkage between N-acetylglucosamine and glucuronic acid in hyaluronan polymers via a substrate-assisted mechanism. In humans, turnover of hyaluronan by this enzyme family is critical for normal extracellular matrix re...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Ling, Bharadwaj, Alamelu G., Casper, Andrew, Barkley, Joel, Barycki, Joseph J., Simpson, Melanie A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Glycobiology and Extracellular Matrices
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666596/
https://ncbi.nlm.nih.gov/pubmed/19201751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900210200
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