Inhibiting the Calcineurin-NFAT (Nuclear Factor of Activated T Cells) Signaling Pathway with a Regulator of Calcineurin-derived Peptide without Affecting General Calcineurin Phosphatase Activity

Calcineurin phosphatase plays a crucial role in T cell activation. Dephosphorylation of the nuclear factors of activated T cells (NFATs) by calcineurin is essential for activating cytokine gene expression and, consequently, the immune response. Current immunosuppressive protocols are based mainly on...

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Bibliographic Details
Main Authors: Mulero, Ma Carme, Aubareda, Anna, Orzáez, Mar, Messeguer, Joaquim, Serrano-Candelas, Eva, Martínez-Hoyer, Sergio, Messeguer, Àngel, Pérez-Payá, Enrique, Pérez-Riba, Mercè
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666591/
https://ncbi.nlm.nih.gov/pubmed/19189965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805889200
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