Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization

A limited repertoire of PPP family of serine/threonine phosphatases with a highly conserved catalytic domain acts on thousands of protein targets to orchestrate myriad central biological roles. A major structural reorganization of human calcineurin, a ubiquitous Ser/Thr PPP regulated by calcium and...

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Udgivet i:PLoS One
Main Authors: Guasch, Alicia, Aranguren-Ibáñez, Álvaro, Pérez-Luque, Rosa, Aparicio, David, Martínez-Høyer, Sergio, Mulero, M. Carmen, Serrano-Candelas, Eva, Pérez-Riba, Mercè, Fita, Ignacio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527731/
https://ncbi.nlm.nih.gov/pubmed/26248042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134569
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