Metamorphic Protein IscU Changes Conformation by cis-trans Isomerizations of Two Peptidyl-Prolyl Peptide Bonds()

IscU from Escherichia coli, the scaffold protein for iron-sulfur cluster biosynthesis and transfer, populates two conformational states with similar free energies and with lifetimes on the order of one second that interconvert in an apparent two-state reaction. One state (S) is structured, and the o...

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Bibliographic Details
Main Authors: Dai, Ziqi, Tonelli, Marco, Markley, John L.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567208/
https://ncbi.nlm.nih.gov/pubmed/23110687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301413y
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