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Metamorphic protein IscU alternates conformations in the course of its role as the scaffold protein for iron–sulfur cluster biosynthesis and delivery

IscU from Escherichia coli, the scaffold protein for iron-sulfur cluster biosynthesis and delivery, populates a complex energy landscape. IscU exists as two slowly interconverting species: one (S) is largely structured with all four peptidyl–prolyl bonds trans; the other (D) is partly disordered but...

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Detalhes bibliográficos
Main Authors: Markley, John L., Kim, Jin Hae, Dai, Ziqi, Bothe, Jameson R., Cai, Kai, Frederick, Ronnie O., Tonelli, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960074/
https://ncbi.nlm.nih.gov/pubmed/23333622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.01.003
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