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pH-Induced Conformational Change of IscU at Low pH Correlates with Protonation/Deprotonation of Two Conserved Histidine Residues

[Image: see text] IscU, the scaffold protein for the major iron–sulfur cluster biosynthesis pathway in microorganisms and mitochondria (ISC pathway), plays important roles in the formation of [2Fe–2S] and [4Fe–4S] clusters and their delivery to acceptor apo-proteins. Our laboratory has shown that Is...

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Библиографические подробности
Главные авторы: Dai, Ziqi, Kim, Jin Hae, Tonelli, Marco, Ali, Ibrahim K., Markley, John L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139155/
https://ncbi.nlm.nih.gov/pubmed/25055301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500313t
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