Location of the Antidepressant Binding Site in the Serotonin Transporter: IMPORTANCE OF SER-438 IN RECOGNITION OF CITALOPRAM AND TRICYCLIC ANTIDEPRESSANTS

The serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belo...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Andersen, Jacob, Taboureau, Olivier, Hansen, Kasper B., Olsen, Lars, Egebjerg, Jan, Strømgaard, Kristian, Kristensen, Anders S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2009
Aiheet:
Membrane Transport, Structure, Function, and Biogenesis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665081/
https://ncbi.nlm.nih.gov/pubmed/19213730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806907200
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