The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

Accumulating evidence suggests that neurons prone to degeneration in Alzheimer's Disease (AD) exhibit evidence of re-entry into an aberrant mitotic cell cycle. Our laboratory recently demonstrated that, in a genomic amyloid precursor protein (APP) mouse model of AD (R1.40), neuronal cell cycle...

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Bibliographic Details
Main Authors: Bhaskar, Kiran, Miller, Megan, Chludzinski, Alexandra, Herrup, Karl, Zagorski, Michael, Lamb, Bruce T
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663563/
https://ncbi.nlm.nih.gov/pubmed/19291319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-14
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