Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27(Kip1) Phosphorylation on Thr187 and Accumulates p27(Kip1) in the Nucleus: Implications for Breast Cancer Therapy

We describe the design of a potent and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI-2418, and its methyl ester GGTI-2417, which increases the levels of the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) and induces breast tumor regression in vivo. Experiments wit...

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Main Authors: Kazi, Aslamuzzaman, Carie, Adam, Blaskovich, Michelle A., Bucher, Cynthia, Thai, Van, Moulder, Stacy, Peng, Hairuo, Carrico, Dora, Pusateri, Erin, Pledger, Warren J., Berndt, Norbert, Hamilton, Andrew, Sebti, Saïd M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663293/
https://ncbi.nlm.nih.gov/pubmed/19204084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01029-08
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