Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27(Kip1) Phosphorylation on Thr187 and Accumulates p27(Kip1) in the Nucleus: Implications for Breast Cancer Therapy

We describe the design of a potent and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI-2418, and its methyl ester GGTI-2417, which increases the levels of the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) and induces breast tumor regression in vivo. Experiments wit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kazi, Aslamuzzaman, Carie, Adam, Blaskovich, Michelle A., Bucher, Cynthia, Thai, Van, Moulder, Stacy, Peng, Hairuo, Carrico, Dora, Pusateri, Erin, Pledger, Warren J., Berndt, Norbert, Hamilton, Andrew, Sebti, Saïd M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663293/
https://ncbi.nlm.nih.gov/pubmed/19204084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01029-08
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge