Pin1 Catalyzes Conformational Changes of Thr-187 in p27(Kip1) and Mediates Its Stability through a Polyubiquitination Process

The cis-trans peptidylprolyl isomerase Pin1 plays a critical role in regulating a subset of phosphoproteins by catalyzing conformational changes on the phosphorylated Ser/Thr-Pro motifs. The phosphorylation-directed ubiquitination is one of the major mechanisms to regulate the abundance of p27(Kip1)...

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Bibliographic Details
Main Authors: Zhou, Wei, Yang, Qiaoyun, Low, Choon Bing, Karthik, Balakrishna Chandrababu, Wang, Yu, Ryo, Akihide, Yao, Shao Q., Yang, Daiwen, Liou, Yih-Cherng
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781992/
https://ncbi.nlm.nih.gov/pubmed/19584057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.022814
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