CBFβ is critical for AML1-ETO and TEL-AML1 activity

AML1-ETO and TEL-AML1 are chimeric proteins resulting from the t(8;21)(q22;q22) in acute myeloid leukemia, and the t(12;21)(p13;q22) in pre-B-cell leukemia, respectively. The Runt domain of AML1 in both proteins mediates DNA binding and heterodimerization with the core binding factor β (CBFβ) subuni...

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Main Authors: Roudaia, Liya, Cheney, Matthew D., Manuylova, Ekaterina, Chen, Wei, Morrow, Michelle, Park, Sangho, Lee, Chung-Tsai, Kaur, Prabhjot, Williams, Owen, Bushweller, John H., Speck, Nancy A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2009
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662647/
https://ncbi.nlm.nih.gov/pubmed/19179469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-147207
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