Autocatalytic Activation of the Furin Zymogen Requires Removal of the Emerging Enzyme's N-Terminus from the Active Site

BACKGROUND: Before furin can act on protein substrates, it must go through an ordered process of activation. Similar to many other proteinases, furin is synthesized as a zymogen (profurin) which becomes active only after the autocatalytic removal of its auto-inhibitory prodomain. We hypothesized tha...

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Autori principali: Gawlik, Katarzyna, Shiryaev, Sergey A., Zhu, Wenhong, Motamedchaboki, Khatereh, Desjardins, Roxane, Day, Robert, Remacle, Albert G., Stec, Boguslaw, Strongin, Alex Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662429/
https://ncbi.nlm.nih.gov/pubmed/19352504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005031
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