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The Critical Contribution of TGF-β to the Induction of Foxp3 Expression and Treg Function

Stimulation of mouse CD4(+) T cells in the presence of TGF-β results in the expression of Foxp3 and induction of Treg function. Stimulation of human CD4(+) T cells under similar conditions results in the expression of Foxp3, but the cells lack regulatory cell function. TGF-β expressed on the surface...

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Main Authors: Shevach, Ethan M., Tran, Dat. Q., Davidson, Todd S., Andersson, John
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662375/
https://ncbi.nlm.nih.gov/pubmed/18395859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200738111
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