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Induction of FOXP3 expression in naive human CD4(+)FOXP3(−) T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype
Thymic-derived natural T-regulatory cells (nTregs) are important for the induction of self-tolerance and the control of autoimmunity. Murine CD4(+)CD25(−)Foxp3(−) cells can be induced to express Foxp3 after T-cell receptor (TCR) activation in the presence of transforming growth factor β (TGFβ) and a...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2018674/ https://ncbi.nlm.nih.gov/pubmed/17644734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094656 |
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