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Induction of FOXP3 expression in naive human CD4(+)FOXP3(−) T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

Thymic-derived natural T-regulatory cells (nTregs) are important for the induction of self-tolerance and the control of autoimmunity. Murine CD4(+)CD25(−)Foxp3(−) cells can be induced to express Foxp3 after T-cell receptor (TCR) activation in the presence of transforming growth factor β (TGFβ) and a...

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Autors principals: Tran, Dat Q., Ramsey, Heather, Shevach, Ethan M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2018674/
https://ncbi.nlm.nih.gov/pubmed/17644734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094656
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