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IL-2 Controls the Stability of Foxp3 expression in TGF-β-induced Foxp3(+) T cells in vivo

Stimulation of naïve mouse CD4(+)Foxp3(−) T cells in the presence of TGF-β results in the induction of Foxp3 expression and T suppressor function. However, Foxp3 expression in these induced T regulatory cells (iTreg) is unstable raising the possibility that iTreg would not be useful for treatment of...

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Bibliografiske detaljer
Main Authors: Chen, Qian, Kim, Yong Chan, Laurence, Arian, Punkosdy, George A., Shevach, Ethan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098943/
https://ncbi.nlm.nih.gov/pubmed/21525380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100061
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