Identification of Neutral Cholesterol Ester Hydrolase, a Key Enzyme Removing Cholesterol from Macrophages

Unstable lipid-rich plaques in atherosclerosis are characterized by the accumulation of macrophage foam cells loaded with cholesterol ester (CE). Although hormone-sensitive lipase and cholesteryl ester hydrolase (CEH) have been proposed to mediate the hydrolysis of CE in macrophages, circumstantial...

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Autors principals: Okazaki, Hiroaki, Igarashi, Masaki, Nishi, Makiko, Sekiya, Motohiro, Tajima, Makiko, Takase, Satoru, Takanashi, Mikio, Ohta, Keisuke, Tamura, Yoshiaki, Okazaki, Sachiko, Yahagi, Naoya, Ohashi, Ken, Amemiya-Kudo, Michiyo, Nakagawa, Yoshimi, Nagai, Ryozo, Kadowaki, Takashi, Osuga, Jun-ichi, Ishibashi, Shun
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662263/
https://ncbi.nlm.nih.gov/pubmed/18782767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802686200
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