Transferrin-a modulates hepcidin expression in zebrafish embryos

The iron regulatory hormone hepcidin is transcriptionally up-regulated in response to iron loading, but the mechanisms by which iron levels are sensed are not well understood. Large-scale genetic screens in the zebrafish have resulted in the identification of hypochromic anemia mutants with a range...

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Bibliografiske detaljer
Main Authors: Fraenkel, Paula G., Gibert, Yann, Holzheimer, Jason L., Lattanzi, Victoria J., Burnett, Sarah F., Dooley, Kimberly A., Wingert, Rebecca A., Zon, Leonard I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2009
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661867/
https://ncbi.nlm.nih.gov/pubmed/19047682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-165340
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