BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin.

Hemojuvelin (Hjv), a member of the repulsive-guidance molecule (RGM) family, upregulates transcription of the iron regulatory hormone hepcidin by activating the bone morphogenetic protein (BMP) signaling pathway in mammalian cells. Mammalian models have identified furin, neogenin, and matriptase-2 a...

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Autors principals:	Yann Gibert, Victoria J Lattanzi, Aileen W Zhen, Lea Vedder, Frédéric Brunet, Sarah A Faasse, Jodie L Babitt, Herbert Y Lin, Matthias Hammerschmidt, Paula G Fraenkel
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2011-01-01
Col·lecció:	PLoS ONE
Accés en línia:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014553&type=printable
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