Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study

The goal of this study was to evaluate the time course of metabolic changes in leukaemia cells treated with the Bcr-Abl tyrosine kinase inhibitor imatinib. Human Bcr-Abl(+) K562 cells were incubated with imatinib in a dose-escalating manner (starting at 0.1 μM with a weekly increase of 0.1 μM imatin...

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Bibliographic Details
Main Authors: Klawitter, J, Anderson, N, Christians, U, Leibfritz, D, Eckhardt, S G, Serkova, N J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661771/
https://ncbi.nlm.nih.gov/pubmed/19259085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604946
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