Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose

AIMS: The immunosuppressant ciclosporin is an efficient prophylaxis against transplant organ rejection but its clinical use is limited by its nephrotoxicity. Our previous systematic studies in the rat indicated urine metabolite pattern changes to be sensitive indicators of the negative effects of ci...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Klawitter, Jost, Haschke, Manuel, Kahle, Christine, Dingmann, Colleen, Klawitter, Jelena, Leibfritz, Dieter, Christians, Uwe
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Blackwell Science Inc 2010
Aiheet:
Human Toxicology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911554/
https://ncbi.nlm.nih.gov/pubmed/20653677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03689.x
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