Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose

AIMS: The immunosuppressant ciclosporin is an efficient prophylaxis against transplant organ rejection but its clinical use is limited by its nephrotoxicity. Our previous systematic studies in the rat indicated urine metabolite pattern changes to be sensitive indicators of the negative effects of ci...

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Autors principals: Klawitter, Jost, Haschke, Manuel, Kahle, Christine, Dingmann, Colleen, Klawitter, Jelena, Leibfritz, Dieter, Christians, Uwe
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2010
Matèries:
Human Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911554/
https://ncbi.nlm.nih.gov/pubmed/20653677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03689.x
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