Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose

AIMS: The immunosuppressant ciclosporin is an efficient prophylaxis against transplant organ rejection but its clinical use is limited by its nephrotoxicity. Our previous systematic studies in the rat indicated urine metabolite pattern changes to be sensitive indicators of the negative effects of ci...

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Hlavní autoři: Klawitter, Jost, Haschke, Manuel, Kahle, Christine, Dingmann, Colleen, Klawitter, Jelena, Leibfritz, Dieter, Christians, Uwe
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2010
Témata:
Human Toxicology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911554/
https://ncbi.nlm.nih.gov/pubmed/20653677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03689.x
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