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Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

Cognitive problems occur in asymptomatic gene carriers of Huntington's disease (HD), and mouse models of the disease exhibit impaired learning and substantial deficits in the cytoskeletal changes that stabilize long-term potentiation (LTP). The latter effects may be related to the decreased pro...

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Detalhes bibliográficos
Main Authors: Simmons, Danielle A., Rex, Christopher S., Palmer, Linda, Pandyarajan, Vijay, Fedulov, Vadim, Gall, Christine M., Lynch, Gary
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660722/
https://ncbi.nlm.nih.gov/pubmed/19264961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811228106
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