Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

Cognitive problems occur in asymptomatic gene carriers of Huntington's disease (HD), and mouse models of the disease exhibit impaired learning and substantial deficits in the cytoskeletal changes that stabilize long-term potentiation (LTP). The latter effects may be related to the decreased pro...

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Detaylı Bibliyografya
Asıl Yazarlar: Simmons, Danielle A., Rex, Christopher S., Palmer, Linda, Pandyarajan, Vijay, Fedulov, Vadim, Gall, Christine M., Lynch, Gary
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660722/
https://ncbi.nlm.nih.gov/pubmed/19264961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811228106
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