Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

Cognitive problems occur in asymptomatic gene carriers of Huntington's disease (HD), and mouse models of the disease exhibit impaired learning and substantial deficits in the cytoskeletal changes that stabilize long-term potentiation (LTP). The latter effects may be related to the decreased pro...

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Bibliographic Details
Main Authors: Simmons, Danielle A., Rex, Christopher S., Palmer, Linda, Pandyarajan, Vijay, Fedulov, Vadim, Gall, Christine M., Lynch, Gary
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660722/
https://ncbi.nlm.nih.gov/pubmed/19264961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811228106
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