Brain-Derived Neurotrophic Factor Restores Synaptic Plasticity in a Knock-In Mouse Model of Huntington's Disease

Asymptomatic Huntington's disease (HD) patients exhibit memory and cognition deficits that generally worsen with age. Similarly, long-term potentiation (LTP), a form of synaptic plasticity involved in memory encoding, is impaired in HD mouse models well before motor disturbances occur. The reas...

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Gepubliceerd in:J Neurosci
Hoofdauteurs: Lynch, Gary, Kramar, Eniko A., Rex, Christopher S., Jia, Yousheng, Chappas, Danielle, Gall, Christine M., Simmons, Danielle A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672319/
https://ncbi.nlm.nih.gov/pubmed/17442827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5113-06.2007
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