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Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

Cognitive problems occur in asymptomatic gene carriers of Huntington's disease (HD), and mouse models of the disease exhibit impaired learning and substantial deficits in the cytoskeletal changes that stabilize long-term potentiation (LTP). The latter effects may be related to the decreased pro...

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Détails bibliographiques
Auteurs principaux: Simmons, Danielle A., Rex, Christopher S., Palmer, Linda, Pandyarajan, Vijay, Fedulov, Vadim, Gall, Christine M., Lynch, Gary
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660722/
https://ncbi.nlm.nih.gov/pubmed/19264961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811228106
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