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Impact of target mRNA structure on siRNA silencing efficiency: a large-scale study

The selection of active siRNAs is generally based on identifying siRNAs with certain sequence and structural properties. However, the efficiency of RNA interference has also been shown to depend on the structure of the target mRNA, primarily through studies using exogenous transcripts with well-defi...

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Bibliografische gegevens
Hoofdauteurs: Gredell, Joseph A., Berger, Angela K., Walton, S. Patrick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658823/
https://ncbi.nlm.nih.gov/pubmed/18306428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.21798
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