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Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells

Design of an efficient delivery system is a generally recognised bottleneck in translation of siRNA technology into clinic. Despite research efforts, cellular processes that determine efficiency of siRNA silencing achieved by different delivery formulations remain unclear. Here, we investigated the...

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Publicat a:Sci Rep
Autors principals: Alshehri, Abdullah, Grabowska, Anna, Stolnik, Snow
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830644/
https://ncbi.nlm.nih.gov/pubmed/29491352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22166-3
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