Antidiabetic drug metformin (Glucophage(R)) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

Epidemiological, clinical and experimental evidence suggests a link between type 2 diabetes and Alzheimer's disease (AD). Insulin modulates metabolism of β-amyloid precursor protein (APP) in neurons, decreasing the intracellular accumulation of β-amyloid (Aβ) peptides, which are pivotal in AD p...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Yaomin, Zhou, Kun, Wang, Ruishan, Liu, Yun, Kwak, Young-Don, Ma, Tao, Thompson, Robert C., Zhao, Yongbo, Smith, Layton, Gasparini, Laura, Luo, Zhijun, Xu, Huaxi, Liao, Francesca-Fang
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656178/
https://ncbi.nlm.nih.gov/pubmed/19237574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807991106
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