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Antidiabetic drug metformin (Glucophage(R)) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
Epidemiological, clinical and experimental evidence suggests a link between type 2 diabetes and Alzheimer's disease (AD). Insulin modulates metabolism of β-amyloid precursor protein (APP) in neurons, decreasing the intracellular accumulation of β-amyloid (Aβ) peptides, which are pivotal in AD p...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2656178/ https://ncbi.nlm.nih.gov/pubmed/19237574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807991106 |
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