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Distinct Dysregulation of Lipid Metabolism by Unliganded Thyroid Hormone Receptor Isoforms
Thyroid hormone receptors (TRs) play critical roles in energy homeostasis. To understand the role of TRs in lipid homeostasis in vivo, we adopted the loss-of-function approach by creating knock-in mutant mice with targeted mutation in the TRα gene (TRα1PV mouse) or TRβ gene (TRβPV mouse). The PV mut...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Endocrine Society
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654517/ https://ncbi.nlm.nih.gov/pubmed/19131509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0311 |
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