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Distinct Dysregulation of Lipid Metabolism by Unliganded Thyroid Hormone Receptor Isoforms

Thyroid hormone receptors (TRs) play critical roles in energy homeostasis. To understand the role of TRs in lipid homeostasis in vivo, we adopted the loss-of-function approach by creating knock-in mutant mice with targeted mutation in the TRα gene (TRα1PV mouse) or TRβ gene (TRβPV mouse). The PV mut...

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Podrobná bibliografie
Hlavní autoři: Araki, O., Ying, H., Zhu, X. G., Willingham, M. C., Cheng, S. Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Endocrine Society 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654517/
https://ncbi.nlm.nih.gov/pubmed/19131509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0311
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